Myelination on Mimetix scaffolds

ME Bechler, A Neuron-Free Microfiber Assay to Assess Myelin Sheath Formation</a>“Oligodendrocytes (pp. 97-110). Humana Press, New York, NY. (2019)

D Allimuthu, Z Hubler, FJ Najm, H Tang, I Bederman, W Seibel,PJ Tesar, DJ Adams. (2019). Diverse Chemical Scaffolds Enhance Oligodendrocyte Formation by Inhibiting CYP51, TM7SF2, or EBP. Cell chemical biology , 26(4), 593-599.

A Dillenburg, G Ireland, RK Holloway, CL Davies, FL Evans, M Swire, ME Bechler, D Soong, T Yuen, G Su, J Bechler, C Smith, A Williams, VE Miron, Activin receptors regulate the oligodendrocyte lineage in health and disease </a>“.Acta neuropathologica, 135(6), 887-906

MS Elitt et al. “Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease.” Stem cell reports 11.3 (2018): 711-726.

MM Fu, TS McAlear, H Nguyen, JA Oses-Prieto, A Valenzuela, RD Shi, … S Bechstedt & BA Barres. (2019). The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for MyelinationCell (2019) 179 (1): 132-146.e14

Y Xu, D Chitsaz, RA Brown, QL Cui, MA Dabarno, JP Antel, T Kennedy, Deep learning for high-throughput quantification of oligodendrocyte ensheathment at single-cell resolution </a>“.Communications Biology 2, Article number: 116 (2019)

AR Malheiro, B Correia, T Ferreira da Silva, D Bessa‐Neto, PP Van Veldhoven, P Brites. Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1‐myristyl ether treatment. Brain Pathology (2019)

Z Hubler, D Allimuthu, I Bederman, MS Elitt, M Mudhavan, KC Allan, HE Shick, E Garrison, M Karl, DC Factor, ZS Nevin, JL Sax, MA Thompson, Y Fedorov, J Jin, WK Wilson, M Giera, F Bracher, RH Miller, PJ Tesar, DJ Adams, Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination </a>“.Nature (2018), 560(7718),372

L Li, E Tian, X Chen, J Chao, J Klein, Q Qu, & Y Shi. (2018). GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hiPSC model of Alexander disease. Cell stem cell, 23(2), 239-251.

M. Bechler, L. Byrne, C. Ffrench-Constant, “CNS Myelin Sheaths are an intrinsic property of Oligodendrocytes”. Current Biology 25, 1-6 September 21, 2015

Biomaterials and Tissue Engineering

L Keller, L Pijnenburg, …N Benkirane-Jessel, Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration </a>“.British journal of ophthalmology 2018

C Ramachandran, V Sangwan, I Ortega, U Bhatnagar, S Mulla, R McKean, S MacNeil, Synthetic biodegradable alternatives to the use of the amniotic membrane for corneal regeneration: assessment of local and systemic toxicity in rabbits </a>“.British journal of ophthalmology 2018

R Santoro, S Venkateswaran, F AmadeoR Zhang, M Brioschi, A Callanan, M Agrifoglio, C Banfi, M Bradley, M Pesce, Acrylate-based materials for heart valve scaffold engineering</a>“.Biomater. Sci., 2018, 6, 154-167

H. R. B. Raghavendran, S. Puvaneswary, S. Talebian, M. R. Murali, S. V. Naveen, G. Krishnamurithy, R. McKean, T. Kamarul “A comparative study on in vitro osteogenic priming potential of electronspun scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for tissue engineering applications” PLoS One 9, 8 (2014), e104389.

A. L. G. Millas, R. McKean, R. Stevens, M. Yusuf, J. V.W. Silveira, M. B. Puzzi, E. Bittencourt “Fabrication of electrospun scaffolds incorporating an Amazonian therapeutic oil from the Copaifera sp. for wound care applications” J. Biomater. Tissue Eng. 4 (2014), pp. 217-220.

P. Deshpande, C. Ramachandran, F. Sefat, I. Mariappan, C. Johnson, R. McKean, M. Hannah, V. S. Sangwan, F. Claeyssens, A. J. Ryand, S. MacNeil “Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants” Biomaterials 34, 21 (2013), pp. 5088–5106.

Cell Culture

M.Leino, C. Astrand, N. Hughes-Brittain, B. Robb, R.McKean, V.Chotteau, Human embryonic stem cell dispersion in electrospun PCL fiber scaffolds by coating with laminin-521 and E-cadherin-Fc</a>“.J.Biomed Mater Res Part B 2017

R. McKean, E.Heister, “Technology Platforms for 3D Cell Culture: A User’s Guide. Chapter 12“. Wiley. ISBN: 9781118851500

L. Al-Khalili,K. Gillner, Y. Zhang, C. Astrand,N. Hughes-Brittain, R.McKean, B. Robb, V.Chotteau, “Characterization of Human CD133+ cells in biocompatible poly(l-lactic acid) electrospun nano-fiber scaffolds“. Journal of Biomaterials and Tissue Engineering, Vol. 6, no 12, 959-966, 2016

A.J.Massey, “Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity“. Nature Scientific Reports 2016

Scaffold Characterisation

R.S.Bradley, I. K. Robinson, Y. Mohammed, “3D X-Ray Nanotomography of Cells Grown on Electrospun Scaffolds“. Macromolecular Bioscience 2016

H. Suhaimi, S. Wang, T. Thornton, D. B. Das “On glucose diffusivity of tissue engineering membranes and scaffolds” Chemical Engineering Science 126 (2015), pp. 244–256.

M. Yusuf, A. L. G. Millas, A. K. C. Estandarte, G. K. Bhella, R. McKean, E. Bittencourt, I. K. Robinson “Platinum blue staining of cells grown in electrospun scaffolds” BioTechniques 57 (2014), pp.137-141.

I. Ortega, R. McKean, A. Ryan, S. MacNeil, F. Claeyssens “Characterisation and evaluation of the impact of microfabricated pockets on the performance of limbal epithelial stem cells in biodegradeable PLGA membranes for corneal regeneration” Biomater. Sci. 2 (2014), pp. 723-734.