Electrospun Biomaterials

The electrospinning process can be used to create synthetic scaffolds for implantation. The advantages electrospinning are the ability to tailor polymer, architecture and structure to create materials suitable for different therapeutic applications.

  • Electrospun nano- and micro- fibres mimic the natural extracellular matrix and provide an ideal substrate for adherent cells.
  • Scaffolds can be synthesised from a range of medical-grade biocompatible polymers which elicit minimal immune response.
  • Scaffolds can be designed to degrade to non-toxic products over periods of 2 weeks to 3 years, or not to degrade at all.
  • Mechanical properties including strength and elasticity can be designed to be consistent with implantation sites.
  • Fibres can be oriented in different alignments to promote the growth and differentiation of different cell types, or to guide cells in particular orientations.
  • The porous architecture (>80-95%) of electrospun scaffolds facilitates cell infiltration and nutrient exchange.

Raw Materials

Electrospun scaffolds can be made from a range of polymers and tailored to optimise mechanical properties, such as stiffness and elasticity, as well as degradation rate. Commonly used synthetic polymers include: Poly Lactides (PLA); Poly Lactide Glycolides (PLGA); Poly Caprolactone (PCL); Poly(lactide-co-caprolactone) (PLCL); Polyurethanes – elastic materials; Polyacrylonitrile (PAN). Biological raw materials can also be electrospun or blended with synthetic polymers.

contact us to discuss what scaffold design would match your needs