The field of cell therapy is advancing apace, driven by innovation in cell engineering and proliferation technology. However, challenges remain that could be addressed with biomaterials. Challenges such as cell implantation, cell retention and immune-shielding. The distinct characteristics of electrospun materials, including scalability, minimal immunogenicity, regulatory familiarity and the ability to create a custom product, mean that they are well suited for these applications.

The Kalyptix®  technology platform comprises an immuno-protective bilayer membrane enclosing cells on carrier scaffolds:

  • NANO layer with tuneable porosity to control diffusion and flux of molecules which acts as a barrier to cells;
  • MICRO layer which is adaptable to a wide range of cells or host tissues.

 

Schematic depiction of a macroencapsulation device

 

Scanning electron microscope image of Kalyptix bilayer

Whitepaper - Electrospun Materials for Macroencapsulation Devices

Cell therapies and regenerative medicine have the potential to produce effective, long-lasting treatments and cures for a range of diseases. Recently there have been major advances in designing, controlling, and tailoring relevant cells and organoids for such cures. This progress has brought the concept of therapeutic cell factories closer to becoming real devices which can act as artificial organs and allow patients to lead a symptom-free life.

As our understanding of the cellular aspects of such treatments becomes more comprehensive, the focus for research and innovation is shifting towards the development of appropriate biomaterials to house the cells so devices can facilitate the efficacy of the therapy.

Download our new White Paper to understand more about the current state of biomaterials for cell encapsulation devices, including electrospun biomaterials and their clinical utility in this growing area.



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    Kalyptix® is the registered trademark of The Electrospinning Company Limited in the UK.