A new publication in PLOSOne describes a study at the University of Malaya which tested whether a biocomposite electrospun scaffold has the ability to induce differentiation of hMSCs into osteogenic lineage without specific growth factors. Three scaffolds were generated by The Electrospinning Company for this purpose: PLLA + collagen, PLLA + hydroxyapatite (HA) and PLLA + collagen/HA. The presence of both collagen and HA on the fibre surface promptly affected differentiation towards an osteogenic lineage, indicating that composite fibres could be beneficial for stem cell-based therapies in bone tissue engineering. Image: 21-day culture of hMSCs in the PLLA + collagen/HA scaffold, showing mineral deposition on the surface of osteoblast-like cells at day 14 and 21 (picture from Raghavendran et al., 2014).
Full paper: H. R. B. Raghavendran et al. “A comparative study on in vitro osteogenic priming potential of electronspun scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for tissue engineering applications in press, DOI: 10.1371/journal.pone.0104389.