Mimetix® scaffolds were used in the recent publication “Phase-contrast 3D tomography of HeLa cells grown in PLLA polymer electrospun scaffolds using synchrotron X-rays” in The Journal of Synchrotron Radiation. This study, led by Dr. M. Yusuf at the University College London (UCL), collaborating with the Research Centre at Harwell (RCAH) and Diamond Light Source on the Harwell Innovation Campus, investigated the use of synchrotron x-ray method to determine the growth of cells in 3D structures. Mimetix® scaffolds are made of electrospun poly l-lactide (PLLA) and are used for cell culture and tissue engineering applications. The team compared two fibre diameters, including 4 microns which is used in commercially available Mimetix products, and examined cell infiltration and cell-cell connectivity over 2, 5 and 8 days. This investigation shows the potential of Mimetix® plates to study complex behaviour of cells in 3D and the potential for imaging technology to study cell-scaffold interactions for future medical use.
You can read more publication on electrospinning method used for tissue engineering applications here.
Acknowledgement: Aga Khan University, Karachi, Pakistan