Stem cell culture in coated scaffolds

A simple 3-D culture system, made of electrospun polycaprolactone (PCL) fibers and coated with defined extracellular proteins that occur naturally in the stem cell niche, allowed dispersed attachment and culture of human pluripotent stem cells devoid of cell aggregation. A publication from The Royal Institute of Technology (KTH), Stockholm describes how PCL fiber scaffolds coated… Read more »

KTP award for smart biomaterial development

The Electrospinning Company and the University of Nottingham have been awarded a Knowledge Transfer Partnership project to develop thermo-responsive scaffolds for 3D cell culture. The Electrospinning Company has a range of materials in development for use in 3D cell expansion in bioreactors, for example to increase the efficiency of the manufacture of stem cells for… Read more »

Muscle progenitor stem cells in 3D maintain character after expansion in Mimetix scaffolds

CD133+ progenitor stem cells were shown to maintain ‘stem-ness’ after expansion¬†in Mimetix 3D cell culture. In a recent publication in the Journal of Biomaterials and Tissue Engineering, researchers at KTH in Sweden characterised the growth and differentiation of CD133+ stem cells in Mimetix 3D and in conventional 2D cell culture. CD133+ cells are myogenic progenitors… Read more »