Electrospun Biomaterials

The electrospinning process can be used to create synthetic scaffolds for implantation. The advantages of this process are the ability to tailor polymer, architecture and structure to create materials suitable for different therapeutic applications.

  • Electrospun nano- and micro- fibres mimic the natural extracellular matrix and provide an ideal substrate for adherent cells.
  • Scaffolds can be synthesised from a range of medical-grade biocompatible polymers to tune mechanical properties and degradation time.
  • Fibres can be oriented in different alignments to promote the growth and differentiation of different cell types, or to guide cells in particular orientations.
  • The porous architecture (>80-95%) of electrospun scaffolds facilitates efficient nutrient exchange.

Polymer Raw Materials

We work with a range of polymers to tailor mechanical properties, such as stiffness and elasticity, as well as degradation rate to different cell types and applications. Where possible we use polymers which have previously been used in medical devices with regulatory documentation.

  • Poly Lactides (PLA) – stiff materials (Young’s modulus GPa range) with degradation rates longer than 3 years
  • Poly Lactide Glycolides (PLGA) – stiff materials that can be tuned to degrade over periods of four weeks to 18 months
  • Poly Caprolactone (PCL) – softer material (Young’s modulus 100s of MPa range) that can be tuned to degrade over two to three years
  • Poly(lactide-co-caprolactone) (PLCL) – elastic material (Young’s modulus 10s of MPa range) that can be tuned to degrade in vivo over 6-18 months
  • Polyacrylonitrile (PAN) – Stiff material which does not degrade

contact us to discuss what scaffold design would match your needs