Why use 3D models in drug discovery?
Cells grown in a 3D micro-environment look and behave much more like cells in human tissues than those cultured in 2D. They are in contact with other cells and produce extracellular matrix, which influences tissue-specific gene expression, cell growth, and the uptake and metabolism of drugs. Therefore, 3D cell-based in vitro assays provide more realistic data in drug discovery testing, for example regarding the efficacy of chemotherapeutic agents against tumour cells, and could potentially reduce the failure rate of drugs following expensive animal studies.
Products for 3D cell-based assays
Black-walled, clear-bottomed 96-well microplates containing our randomly-orientated electrospun fibre will be available soon. Our randomly orientated fibres have been shown to support the growth of primary cells, stem cells and standard cell lines. Please Contact Us for further information.